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Venkata Sumanth Reddy Gutty

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Review Open access Aug 2026

Mechanisms of and mitigating strategies for cellular immune responses to CRISPR-associated nucleases in genome editing therapy

Immunogenicity of CRISPR-associated nucleases (Cas) is a critical barrier to the development of safe and effective genome editing therapies. These proteins inherently pose a risk of immune recognition due to their prokaryotic origins. A multitude of factors, such as the delivery vehicle, the route of administration, co...

Bryan Hu, Venkata Sumanth Reddy Gutty, Roland W. Herzog et al. · 0 citations

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