Targeting CDC42 with CASIN Reprograms Cell-Type-Specific Transcriptomes and MAPK-Driven Transcription Factor Networks in the Aging Brain
Background Parkinson’s disease (PD) is driven by α-synuclein (α-syn) aggregation and affects vulnerable dopaminergic and GABAergic neurons, and its incidence rises dramatically with age. In our α-syn mouse model, motor impairment required both α syn oligomers and the aging milieu, and pharmacological inhibition of the...