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Verity F. T. Mitchener

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Open access Jul 2026

TRPML1 loss drives lysosomal calcium failure and astrocyte dysfunction across Alzheimer’s Disease progression

It is found that astrocytic cytosolic calcium activity is suppressed prior to amyloid plaque deposition and is accompanied by reduced lysosomal acidification in vivo, identifying lysosomal failure as an initiating event in astrocyte dysfunction in AD.

D. Shah, P. Desai, C. Chertavian et al. · 0 citations
Open access Jul 2026

Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease

Glycolytic inhibition of glycogenolysis blunted microglia responses to Abeta aggregates and markedly reduced Abeta uptake, confirming a functional role for glycogen metabolism in shaping microglial states and highlighting glycogen homeostasis as a potential therapeutic target for promoting Abeta clearance and preservin...

Hannah McAlister, Heather Merchant, Verity F. T. Mitchener et al. · 0 citations

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