MEDICINAL PHYTOCHEMICALS TARGETING TOBACCO INDUCED ORAL DYSBIOSIS AND BIOFILM FORMATION: MECHANISMS, THERAPEUTIC POTENTIAL, AND FUTURE PERSPECTIVES
Tobacco consumption is a major modifiable risk factor for oral diseases, particularly periodontitis, owing to its profound effects on the oral microbiome and biofilm development. Exposure to tobacco smoke disrupts microbial homeostasis, resulting in oral dysbiosis characterized by enrichment of pathogenic species such...