Author

Victor L. J. Tybulewicz

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Review Open access Oct 2026

Beyond ion homeostasis: WNK1 and the role of water influx in T cell biology

The serine-threonine kinase WNK1 is a regulator of ion homeostasis and cell volume control studied most extensively in the kidney. WNK1 phosphorylates and activates the OXSR1 and STK39 kinases, which in turn phosphorylate members of the SLC12A-family of ion co-transporters resulting in influx of Na + , K + and Cl...

Robert Köchl, Victor L. J. Tybulewicz · Frontiers in Immunology · 0 citations

Open access Oct 2026

Dynamics of human cardiogenesis and its disruption in trisomy 21.

Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches1. Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a context-aware, resolution-agnostic niche classificat...

J. Cranley, Kazumasa Kanemaru, S. Bayraktar et al. · Nature · 0 citations