Open access
Sep 2026
Selective Thrombin Modulation by AYA1809002: Stability and On-Demand Reversal of an Exosite I-Targeting Aptamer
Background: Thrombin is a central mediator of coagulation and platelet activation and a key anticoagulant target. Direct thrombin inhibitors broadly suppress thrombin proteolytic activity, potentially disrupting procoagulant and anticoagulant signaling. Exosite-targeting aptamers may enable selective modulation and pro...
M. Ayass, N. Griko, Victor Pashkov et al.
· Pharmaceuticals · 0 citations