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Vigneshwar Reddy Ashireddygari

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Open access Aug 2026

SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death

It is shown that variations in SARS-CoV-2 ORF3a correlate with the pathogenic potential of VOCs and drive Delta variant-specific lysosomal damage that activates inflammatory cell death and disrupts lysosomal homeostasis and triggers cell death.

Ayushi Amin Dey, Sanchita Mishra, Vigneshwar Reddy Ashireddygari et al. · Communications Biology · 0 citations