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Author

Vikas Mehta

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Open access Sep 2026

Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis

Immune checkpoint inhibitor (ICI) therapy triggers complications that are currently attributed solely to immune activation. We hypothesized that target tissue–specific mechanisms also play a role and studied these mechanisms in thyrocytes. We found that thyroidal PD-L1 acts as a cytoprotective regulator, promoting cell...

Mihaela Stefan-Lifshitz, Nicola Viola, O. Meshcheryakova et al. · 0 citations

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