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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Vince Cataldi

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Open access Sep 2026

An Ultrasensitive Luciferase Reporter Reveals Low-Level Extrahepatic mRNA Expression for Enhanced Apparent Biodistribution of Lipid Nanoparticles

Reporter mRNAs are widely used to screen lipid nanoparticle (LNP) formulations and characterize functional mRNA expression in vivo, yet conventional firefly luciferase (FLuc) imaging fails to detect low-level expression. Consequently, weak or absent FLuc signal can be misinterpreted as failed LNP delivery or translatio...

Vince Cataldi, S. Chakraborty, Adam W. G. Alani · 0 citations

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