Aug 2026
Rapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner.
It is shown that combining antimalaria drug chloroquine with rapamycin attenuates the severity of hepatic lipid deposition observed with rapamycin monotherapy, and a crucial dependency on ERRα activity for the observed amelioration of rapamycin-induced hepatic steatosis by chloroquine addition.
Wafa B’chir, C. Dufour, Sylvia Andrzejewski et al.
· Journal of Endocrinology · 0 citations