Author

Vincent Timmerman

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Open access Jul 2026

Stress-induced recruitment of small heat shock protein 1 at the outer mitochondrial membrane underlies resistance to apoptosis

Findings indicate that HSPBs, particularly HSPB1 may contribute to mitochondrial stress adaptation prior to Cytochrome c release, which may underlie the modulation of stress-related and degenerative disease progression and contribute to the chemoresistance associated with cancer, which have been attributed to HSPBs.

Ayesha Kiran Mendes, Stijn L. M. In 't Groen, V. de Winter et al. · Cell Death Discovery · 0 citations

Open access Jul 2026

HDAC6 inhibition alleviates mitochondrial trafficking in models of Charcot-Marie-Tooth disease type 2A

A variant-specific insight is revealed into CMT2A disease mechanisms and HDAC6 is confirmed as a promising target for further therapeutic development by showing that mitochondrial trafficking defects could be alleviated by treatment with an HDAC6 inhibitor.

Lydia H. Jestice, Larissa Butler, Rebecca A. Lea et al. · JCI Insight · 0 citations