Impact of genetic polymorphisms on the response to transdermal fentanyl in cancer patients—a single-center, prospective, biological study
Background/objectives Transdermal fentanyl (TDF) is widely used for moderate-to-severe cancer pain, yet substantial variability in fentanyl exposure, analgesic response, and tolerability remains incompletely explained by clinical factors. We evaluated whether pharmacogenetic variability is associated with pharmacokinet...