Structural biology is moving beyond the determination of static molecular structures toward quantitative descriptions of biomolecular mechanisms. Modern questions increasingly focus on conformational heterogeneity, exchange kinetics, weak and transient interactions, allostery, disorder, assembly, and phase behavior. Th...
J. Purslow, Vincenzo Venditti· Frontiers in Molecular Biosc...· 0 citations
Significance Allosteric regulation enables proteins to transmit signals over long distances, but the mechanisms linking local ligand binding to global conformational changes remain difficult to resolve. Here, we combine NMR-based chemical shift covariance analysis with computational contact-response analysis to map the...
Aayushi Singh, Daniel Burns, Sergey L. Sedinkin et al.· Proceedings of the National...· 0 citations
The backbone 1H, 15N, 13C chemical shift assignment of E. coli AlkB in complex with Zn2+ and α-ketoglutarate is reported, allowing investigations of the protein structural dynamics anticipated to provide crucial insight regarding fundamental aspects in the recognition and enzyme regulation processes.
Sayan Das, J. Purslow, Kyle Malcom et al.· Biomolecular NMR Assignments· 0 citations
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