This review critically summarizes and discusses the progress made in the design, synthesis, and anticancer evaluation of triazolopyrimidine-based organic and inorganic scaffolds reported in the scientific literature over the past five years, with an emphasis on their mechanisms of action and future therapeutic prospect...
I. Lumb, Jaskirat Singh, Yukta Soni et al.· Mini-Reviews in Medical Chem...· 0 citations
Plastic waste presents a persistent environmental burden, yet its constituent polymers represent structurally valuable chemical feedstocks. Mechanical recycling remains limited due to polymer degradation, additive contamination, and material downcycling, underscoring the need for alternative strategies. Chemical upcycl...
UV-visible spectroscopic titrations demonstrated that compound 8b binds monomeric heme more selectively than CQ at both physiological and digestive vacuole pH, supporting inhibition of hemozoin formation as its primary mode of action.
Anuradha Saini, Sumit Kumar, B. Pradines et al.· RSC Advances· 0 citations
Overall, the cytotoxic effects of 7k on MV4-11 cells are attributed to the coordinated induction of ROS-mediated oxidative stress, G0/G1 cell cycle arrest, and caspase-dependent apoptosis, highlighting its promising antiproliferative potential.
