Author

Viren A. Baharani

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Open access Sep 2026

Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection

A nanobody discovery pipeline incorporating competition-based yeast surface display assays is optimized to isolate single-chain variable heavy chain-only antibody domains (VHHs or nanobodies) that bind human ACE2 and inhibit SARS-CoV-2 entry, showcasing their potential as broadly acting receptor-targeted biologics agai...

A. Bakasis, Rachel Patejak, Peter C. Fridy et al. · bioRxiv · 0 citations

Open access Aug 2026

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognition

Two human-derived monoclonal antibodies are characterized that recognize conserved epitopes on the SARS-CoV-2 RBD and retain activity across antigenically distinct variants, and conserved, mutationally constrained epitopes may serve as targets for vaccines designed to elicit antibody responses resilient to ongoing SARS...

M. Abernathy, William B. Foreman, Jasmyn A. Lopez et al. · bioRxiv · 0 citations