Virginia E. Rivero

Chronic TLR7 activation promotes expansion of activated CD11c+ double-negative B cells and autoreactive humoral responses in lupus-like autoimmunity

Age-associated B cells (ABCs) have emerged as a distinct B cell population associated with aging, chronic inflammation, and autoimmunity. Notably, the expansion of ABC-like CD11c-expressing B cells has been observed in patients with systemic lupus erythematosus and in experimental models of lupus-like disease, suggesti...