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Author

Vittorio Sartorelli

2 papers indexed here

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Open access Oct 2026

DND1–NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3′-UTRs

Summary: Primordial germ cell survival requires joint function of the RNA-binding proteins DND1 and NANOS3; yet, how they collaborate was not established. Here, we discover a paradigm of “two-factor authorization”, where RNA-binding proteins with low (DND1) or no (NANOS3) sequence-specificity jointly repress RNAs via a...

Masataka Suzawa, Chen Qiu, A. Polash et al. · 0 citations
Open access Sep 2026

Chromatin modifiers KMT2D, cBAF, and p300 cooperatively facilitate de novo binding of transcription factors on enhancers

Transcription factors (TFs) bind to enhancers and recruit H3K4me1 methyltransferase KMT2D, chromatin remodeler cBAF, and H3K27 acetyltransferase p300 to activate transcription. However, the role of chromatin modifiers in regulating de novo binding of TFs on enhancers remains unclear. Using a robust nuclear transloc...

Hieu T. Van, Young-Kwon Park, D. Wan et al. · 0 citations

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