Author

Vivian Wang

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Aug 2026

CD59 organizes the plasma membrane to sustain oncogenic Ras-MAPK signaling and is a targetable vulnerability in acute myeloid leukemia

Findings reveal CD59 as a critical regulator of Ras-MAPK signaling required for AML growth and nominate its rILYd4-mediated degradation as a therapeutic strategy.

Abdula Maher, Dhanoop Manikoth Ayyathan, S. Cathelin et al. · bioRxiv · 0 citations