Author

Viviana Vargas-López

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Open access Sep 2026

Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum

Mild cognitive impairment (MCI) represents a prodromal stage of Alzheimer’s disease (AD), but the metabolic mechanisms underlying early neuronal dysfunction remain incompletely understood. GABAergic neurons, which maintain excitatory–inhibitory balance and network stability, exhibit early vulnerability during neuro...

Andrea Angarita-Rodríguez, Johan H. Largo-González, Julián Pérez-Mejía et al. · Frontiers in Systems Biology · 0 citations

Open access Aug 2026

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression

[This corrects the article DOI: 10.3389/fbinf.2026.1816121.].

Andrea Angarita-Rodríguez, Viviana Vargas-López, Andrés Pinzón et al. · Frontiers in Bioinformatics · 0 citations

Open access Jul 2026

Comparative evaluation of reference-free transcriptomic deconvolution highlights the importance of biological validation in astrocytes across Alzheimer’s disease

A comparative framework evaluating two complementary unsupervised approaches, CDSeq and DECODER, to reconstruct astrocyte-associated transcriptomic profiles from human hippocampal samples spanning control, mild cognitive impairment, and AD stages establishes a reproducible strategy for evaluating deconvolution methods...

Laura Rodríguez-Millan, Andrea Angarita-Rodríguez, Viviana Vargas-López et al. · Frontiers in Bioinformatics · 0 citations