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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Volkhard Helms

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Open access Sep 2026

Relating transcriptomics to protein abundance reveals self‐driven versus interactor‐driven proteins

Statistically modeling the interdependence between transcriptomics and protein abundances remains a persistent challenge in bioinformatics research. Transcriptomic data and proteomic abundances typically display a moderate Pearson's correlation of about 0.5, while in tumor conditions, the correlation may decrease to a...

Loulwah Arnaout, Volkhard Helms, Aram N. Papazian · 0 citations
Open access Aug 2026

MetaTIS: a tool to predict cognate and near-cognate translation initiation sites in human

A meta-model termed MetaTIS was implemented by combining outputs of genomic and protein language models fine-tuned on Ensembl annotations of transcripts and five different TIS datasets, which proficiently differentiates between spurious and true TIS in four distinct test sets, for both AUG and non-AUG instances.

Aram N. Papazian, Volkhard Helms · 0 citations
Open access Aug 2026

Stress induces DCP2 translation via a stalling-dependent mechanism

DCP2, encoding a major mRNA decapping enzyme, is identified as a previously unrecognized ISR-induced transcript and it is shown that translational induction of DCP2 depends on an overlapping ORF whose conserved 3′ region, corresponding to a ribosome pausing site, acts as a potent inhibitory element.

Roiuk Mykola, Marilena Neff, Taja Vatovec et al. · 0 citations

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