Design, Optimization, and Characterization of Nilotinib-loaded Supersaturable Self-nanoemulsifying Drug Delivery Systems for Improved Anticancer Efficacy
Nilotinib is a weakly basic, BCS Class II tyrosine kinase inhibitor with poor aqueous solubility, which may limit its oral bioavailability, particularly at higher gastrointestinal pH. In the present study, a supersaturable self-nanoemulsifying drug delivery system (sSNEDDS) was systematically developed using castor o...