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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

W. Chan

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Open access Jul 2026

Spatial tissue analysis of secondary sarcoma following CAR T cell therapy for B cell lymphoma

The prevalence of CAR-positive T cells in patient-derived tissue sections, observed metabolic and proliferative shifts in the tumor and its microenvironment, and immune checkpoint analysis provide insights into post-CAR T secondary cancers and highlight tools that may guide future targeted therapies.

Jia-Jye Lee, Peirong Hu, Kun Luo et al. · 0 citations
Jul 2026

Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.

A trispecific CAR targeting CD19, CD20, and CD22 with OX40 co-stimulatory domain with overall response rate was 50%, including complete responses in 83% of lymphoma patients, and one-year overall survival rate was 61%, with durable remissions observed in lymphoma.

S. Vasu, N. Denlinger, No-Joon Song et al. · 0 citations
Review Open access Jul 2026

Genetic engineering strategies for cell-based therapy: viral, non-viral, and precision genome editing technologies

This article provides a comprehensive literature review and compares different approaches on viral, non-viral and precision genome editing technologies, aiming to provide an overview and guidelines for methods selection during clinical CAR-T cell manufacturing.

W. Chan, Marcos de Lima · 0 citations

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