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Author

W. Clemons

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Open access Sep 2026

Structures of the lipid II flippase from the monoderm pathogen Staphylococcus aureus.

Peptidoglycan biogenesis requires membrane flippases to translocate lipid-linked precursors across the cytoplasmic membrane for processing. This essential step is mediated by MurJ, the lipid II flippase conserved across all peptidoglycan-producing bacteria. While MurJ from diderm bacteria has been structurally resolved...

Yan-Cheng E. Li, Grace F. Baron, W. Clemons · 0 citations
Open access Jul 2026

Rationally Engineered, Chemically Stable Tunicamycin Analogues Decouple DPAGT1 Inhibition from Non-Selective Toxicity

Tunicamycin cyclitol analogues are established as a structurally distinct class of selective DPAGT1-targeted anticancer agents and it is demonstrated that stabilization of the glycosidic linkage is an effective strategy for enhancing pharmacological selectivity, improving in vivo performance, and simplifying the synthe...

Katsuhiko Mitachi, A. Sánchez‐Ruiz, D. Mingle et al. · 0 citations

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