Author

W. D. Arnold

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Review Open access Aug 2026

Reframing sarcopenia as a disease of the ageing motor system.

Sarcopenia is a major driver of disability, frailty, and loss of independence in ageing populations. Current consensus definitions have shifted from low muscle mass to low muscle strength and impaired physical performance as the defining clinical features. The underlying disease model, however, has remained predominant...

L. B. R. Orssatto, W. D. Arnold, L. Ferrucci et al. · The Lancet Healthy Longevity · 1 citation

Open access Sep 2026

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice

ABSTRACT Age‐related weakness is strongly associated with disability and mortality in older adults. While muscle atrophy contributes to weakness, strength declines at a faster rate than muscle mass, implicating neural mechanisms such as changes at the spinal cord and neuromuscular junction. Yet, the role of the motor c...

Jose A. Viteri, Nathan R. Kerr, Fereshteh B. Darvishi et al. · Aging Cell · 0 citations

Open access Jul 2026

CRISPR-SWITCH (silent mutations with intention to create heterozygotes): a strategy for monoallelic genome editing and generation of a Syt1-D365E mouse model of Baker–Gordon syndrome

CRISPR-SWITCH is presented, a genome engineering strategy that enables deliberate monoallelic editing by exploiting allele-specific CRISPR targeting and can enforce heterozygosity at endogenous loci and enable the generation of viable mammalian models for dominant-negative and dosage-sensitive genetic disorders.

Samantha Norris, Sai Goutham Reddy Yeddula, E. Su et al. · Frontiers in Genome Editing · 0 citations