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Author

W. Freeman

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3 papers indexed here

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Open access Oct 2026

A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging

DNA modifications are epigenetic marks added directly to DNA bases that can stably or dynamically regulate gene expression, allowing cells to maintain their identity while also having flexibility to adapt to changes in their environment1. Aging is often thought to disrupt this regulation, causing cells to lose their id...

Sarah R. Ocañas, Walker Hoolehan, Kevin Pham et al. · 0 citations
Open access Oct 2026

Female microglia show heightened responses to aging and amyloid pathology in mice and humans

INTRODUCTION Alzheimer’s disease (AD) displays pronounced sex differences, with women exhibiting greater prevalence and pathological burden than men. However, the molecular mechanisms underlying these differences remain elusive. Translation of preclinical findings to human AD remains challenging, potentially due to lim...

Jillian E. J. Cox, Ewa Poljańska, Sarah Ray et al. · 0 citations

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