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Author

W. Frishman

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Review Jul 2026

Efficacy and Safety of Selective Aldosterone Synthase Inhibitors in Uncontrolled Hypertension: A Systematic Review and Dose-Specific Network Meta-Analysis of Randomized Controlled Trials.

Selective aldosterone synthase inhibitors (ASIs), including baxdrostat and lorundrostat, target CYP11B2 while sparing cortisol synthesis, offering a novel strategy for resistant and uncontrolled hypertension. Yet existing meta-analyses have included nonselective agents or omitted the latest phase 3 data. We searched Pu...

N. Hammad, M. Elkasaby, A. Gadelmawla et al. · 1 citation
Review Aug 2026

Polycystic Ovary Syndrome and Cardiovascular Risk: Mechanisms, Clinical Evidence, and Prevention Strategies.

This focused narrative review synthesizes contemporary evidence on the mechanistic, subclinical, and clinical links between PCOS and cardiovascular disease and examines how hyperandrogenism may contribute to insulin resistance and related abnormalities, including dyslipidemia, hypertension, metabolic dysfunction-associ...

M. Moore, R. Hirani, Samy Khessib et al. · 0 citations
Review Sep 2026

Management of Patent Ductus Arteriosus in the Adult Population.

This review covers the management of PDA in adults, highlighting the pathophysiology, morphological classification, clinical presentation, and current approaches to closure, with transcatheter closure currently the preferred approach.

Anthony J. Kaywood, Alishah Ahmadi, W. Frishman · 0 citations
Review Sep 2026

Safety and Glycemic Efficacy of Perioperative Liraglutide in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Perioperative hyperglycemia in cardiac surgery is associated with wound infection, acute kidney injury, and death, yet the intravenous insulin used to treat it is itself coupled to hypoglycemia, yet the intravenous insulin used to treat it is itself coupled to hypoglycemia.

Ibrahim Gamal, M. Elkasaby, Osama Ewidat et al. · 1 citation
Review Aug 2026

Efficacy and Safety of Baxdrostat for Patients With Uncontrolled or Resistant Hypertension: A Systematic Review and Meta-Analysis.

Baxdrostat lowers blood pressure and aldosterone levels in uncontrolled and resistant hypertension but increases potassium and modestly reduces eGFR, supporting careful laboratory monitoring and longer trials to evaluate long-term clinical outcomes.

A. Gadelmawla, A. Hageen, R. Rateb et al. · 0 citations
Aug 2026

Patent Ductus Arteriosus.

Patent ductus arteriosus (PDA) is a common congenital heart defect. PDA disproportionately affects low-birth-weight infants, resulting in an incidence of 21% among preterm births as compared to 0.05% in the general population. The ductus arteriosus remains patent in the fetus, allowing maternal blood to directly enter...

Rithvik Swamynathan, L. Dolan, W. Frishman et al. · 0 citations
Aug 2026

Updates on Imaging Modalities for the Diagnosis of Aortic Stenosis.

Integration of echocardiography, computed tomography, CMR, and emerging positron emission tomography and artificial intelligence-based approaches can help address diagnostic uncertainty in aortic stenosis.

H. Itani, M. Moumneh, Ahmed A. Zayed et al. · 0 citations

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