Aug 2026
In trans RNA replication of a defective self-amplifying RNA lowers RNA replication but enhances protein translation.
The effects of combining replication-competent and replication-deficient replicons on RNA replication and GOI translation are reported, highlighting the delicate balance between RNA replication and protein synthesis in the context of cellular cytotoxity and metabolic burden.
D. S. Moreno-Gutiérrez, A. L. Duran-Meza, W. Gelbart
· Journal of Molecular Biology · 0 citations