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W. Gerwick

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Review Open access Oct 2026

Marine Filamentous Cyanobacteria: A Review on Biodiversity, Biosynthetic Potential, and Bioactive Natural Product Research

Marine filamentous cyanobacteria have been a productive source of biologically active and structurally unique natural products, some of which have inspired the production of analogs with documented therapeutic efficacy in the clinic. Here we provide a perspective on their ecological, biochemical and chemical attributes...

Seena Jose, Saranya Madiyan, Byeol Ryu et al. · 0 citations
Open access Aug 2026

Canalesolide A, a Structurally Unique Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania sp. with Potent Antitrypanosomal Activity

Canalesolide A displays potent, low nanomolar antitrypanosomal activity against human-infective subspecies of T. brucei with rapid elimination of parasites within 1 h at 1 μM, and preliminary in vivo efficacy/toxicity studies in infected mice suggest a narrow therapeutic window highlighting the need for improved select...

Thaiz R. Teixeira, Byeol Ryu, Richard Cox et al. · 0 citations

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