Author

W. Jin

2 papers indexed here

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Open access Sep 2026

Tumor-derived MG53 aggravates gastrointestinal cancer cachexia related muscle atrophy by inhibiting the TLR4/PI3K/AKT/FOXO3a signaling pathway

Background Cancer cachexia is a multisystem syndrome characterized by progressive skeletal muscle atrophy, anorexia, and weight loss, imposing a substantial global health burden. Gastrointestinal cancer cachexia is highly prevalent, yet its pathogenesis remains poorly understood, and there is currently a lack of effect...

Yong-Fei Wang, Yuan-Yuan Xin, Si-Yuan Wang et al. · Frontiers in Oncology · 0 citations

Review Open access Sep 2026

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

Cancer heterogeneity drives therapeutic failure, resistance, and relapse and encompasses variation across genetic, cellular, tissue, organ, and systemic scales. Existing frameworks define malignant capabilities and tumor–microenvironment interactions but less explicitly address how heterogeneity propagates across scale...

Yong-Lin He, Liang Niu, Yan-Ming Ren et al. · Signal Transduction and Targ... · 0 citations