W. Leonhard

Targeted analysis of salicylate binding partners in renal epithelial cells reveals major AMPK dependency.

The findings indicate that for a large part, the effects of salicylate on targets related to cellular metabolism, cell proliferation and inflammation are dependent on its activation of AMPK, but salicylate induces mitochondrial uncoupling and inhibition of heme synthesis, while other AMPK activators do not, revealing A...