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Sep 2026

Auranofin Sensitizes Oral Squamous Cell Carcinoma to PD-1 Blockade Through DUSP1-Associated Macrophage Reprogramming.

Oral squamous cell carcinoma (OSCC) is frequently refractory to immune checkpoint blockade, in part because the tumor microenvironment is enriched with immunosuppressive, M2-like tumor-associated macrophages. Auranofin (ARN), an FDA-approved thioredoxin reductase inhibitor, induces oxidative and proteotoxic stress and...

Li-Xia Zhang, C. R. Nascimento, W. Magner et al. · 0 citations

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