Artificial membraneless organelles (MLOs) are emerging as spatial organizers in synthetic biology, yet their applications remain largely confined to post-translational regulation. Here, we engineer synthetic condensates that act as modular hubs for targeted mRNA sequestration, enabling programmable post-transcriptional...
Jun-Tao Ke, L. Wan, Ye-Hong Cao et al.· Metabolic Engineering· 0 citations
A thermostable laccase from Thermincola ferriacetica (Thfe-Lac) that is capable of transforming AFB1 in the absence of mediators is identified and represents efficient mediator-free laccase for decontamination of AFB1 in food and feed systems.
Bin-Bin Ouyang, Jiahao Gu, Wei Xu et al.· Food Research International· 0 citations
This review systematically summarizes current bioproduction strategies for L-cysteine, covering biocatalytic pathways and metabolic engineering of microbial cell factories and three mainstream microbial chassis, including Escherichia coli, Corynebacterium glutamicum, and Pantoea ananatis.
Ming-Li Zhao, Di Wu, Yu-Ting Liao et al.· Critical Reviews in Biotechn...· 0 citations
A systems-level host engineering framework in Escherichia coli is established to improve indigo biosynthesis and modulation of cell division and central carbon metabolism alleviates envelope stress and enhances reducing power for indigo formation.
Heng Hu, Meng-Ying Jiang, Yan Zheng et al.· Journal of Agricultural and...· 0 citations
Hydrophobic microenvironment engineering might represent a promising strategy for modulating proton transfer and provide a potential framework for improving the activity of ZEN lactonases for food and feed detoxification.
Bin-Bin Ouyang, Zhao Huang, Chen-Shuo Song et al.· Journal of Agricultural and...· 0 citations
Results demonstrate that B. vulgaris UGT73C21 is an efficient biocatalyst for ginsenoside Rh2 biosynthesis, and significantly enhanced enzyme activity, whereas other tested metal ions reduced it.
Fan Xu, Yu-Ting Liao, Yulei Zhang et al.· Enzyme and Microbial Technol...· 0 citations
2'-Fucosyllactose (2'-FL), the most abundant human milk oligosaccharide (HMO), has attracted considerable interest for its prebiotic and immunomodulatory functions, with broad applications in infant nutrition. In this study, we report the development of a high-yield, genome-integrated 2'-FL-producing strain based on Es...
Rou-Lin Chen, Longhao Yang, Hao Wang et al.· Enzyme and Microbial Technol...· 0 citations
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