Abstract Background Differentiating late-life depression (LLD) from prodromal or early Alzheimer’s disease (AD) is clinically difficult because affective and cognitive symptoms overlap and a subset of LLD patients shows amyloid-β (Aβ) positivity, limiting the specificity of core CSF Aβ/tau biomarkers. The p75 neurotrop...
W. Omori, N. Kajitani, M. Okada-Tsuchioka et al.· International Journal of Neu...· 0 citations
Abstract Background Treatment-resistant schizophrenia (TRS)—defined as insufficient response to at least two different atypical antipsychotics—affects approximately 20–33% of individuals with schizophrenia and has been linked to dopamine D₂-receptor supersensitivity. Although clozapine is the internationally recommende...
T. Nagao, Y. Fujita, G. Sato et al.· International Journal of Neu...· 0 citations
The p75 neurotrophin receptor ectodomain (p75NTR‐ECD) has been implicated in amyloid‐β‐related neurotoxicity, but cerebrospinal fluid (CSF) levels in late‐life depression (LLD) remain uncertain. We compared clinically diagnosed Alzheimer's disease (AD), LLD, and healthy controls (HC) and reassessed exploratory symptom...
W. Omori, N. Kajitani, M. Okada-Tsuchioka et al.· Neuropsychopharmacology Repo...· 0 citations
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