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Open access Sep 2026

Mechanochemical energy landscapes under force support catch–slip bonds in T-cell activation

A minimal two-dimensional TCR–pMHC mechanochemical energy-landscape model is formulated in which peptide-dependent allosteric binding geometry, hinge elasticity, receptor extension, binding-site separation and applied force jointly determine the activation barrier and bond lifetime.

Yogesh B. Bali, Alan D. Rendall, W. Quapp · 0 citations

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