Open access
Oct 2026
A multiparametric in vitro strategy for small molecule drug-induced liver injury risk mitigation in early drug development
Abstract Drug-induced liver injury (DILI) remains a major cause of preclinical and clinical attrition, reflecting persistent gaps in the predictive translation of preclinical safety data to human outcomes. To address these gaps, we established a refined multiparametric framework for early DILI risk prediction using a b...
L. Norona, Fjodor Melnikov, Tomomi Kiyota et al.
· Toxicological Sciences · 0 citations