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Author

W. Richer

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Open access Aug 2026

Altered follicular immunity in secondary lymphoid organs is associated with interferon hyperactivity in Down syndrome

Using multimodal single-cell and spatial profiling of human tonsils, extensive remodeling of immune organization in trisomy 21 is identified and identified as a unique human context to investigate how chronic interferon-associated inflammation reshapes lymphoid tissue organization and adaptive immune cell fate decision...

J. Dutto, Jeremías Bustos, Lucía Boffelli et al. · 0 citations
Open access Aug 2026

Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer

Overall, tumor-invaded LNs and tumors coordinate the generation and maintenance of tumor-reactive CD4+ lineages, identifying highly plastic follicular T cells as therapeutic checkpoints to reinforce anti-tumor responses.

Jimena Tosello Boari, W. Richer, Y. Missolo-Koussou et al. · 0 citations

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