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Author

W. Shihoya

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Open access Oct 2026

Rotation of the N-terminal helix triggers Gα activation.

Heterotrimeric G proteins, activated by G-protein-coupled receptors (GPCRs), are central mediators of cellular signaling. Activation requires GDP release from the Gα subunit, a step attributed largely to the C-terminal α5 helix, the primary GPCR-interacting region. Contributions from other Gα regions have remained uncl...

Hiroki Arai, Tatsuya Ikuta, Ryoji Kise et al. · 0 citations
Open access Aug 2026

Characterisation of a human monoclonal antibody targeting a conserved epitope at the base of the HA head of influenza A(H3N2) virus

Summary Background Numerous broadly reactive human monoclonal antibodies (mAbs) against the haemagglutinin (HA) of influenza A viruses have recognised conserved epitopes across HA subtypes or within subtypes. Most heterosubtypic mAbs target the HA stem, the receptor-binding site (RBS), or the trimeric interface. Althou...

S. Yamayoshi, T. Hamabata, Yuka Inoue et al. · 0 citations

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