Open access
Sep 2026
Orphan nuclear receptor 4A (NR4A) ligands induce ferroptosis and modify immune function in colon cancer
Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 exhibit pro-oncogenic activities in most solid tumors, and this study investigates the role of both receptors and the dual NR4A1/2 1,2-bis(3’-indolyl)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) ligands as inducers of ferroptosis in colon cancer cells. DIM-3,5 ligands...
A. R. Oany, Srijana Upadhyay, Gus A. Wright et al.
· Cell Death Discovery · 0 citations