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Author

William Valdar

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2 papers indexed here

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Open access Aug 2026

Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice

Abstract Severe disease following infection with SARS-CoV or SARS-CoV-2 is driven in part by genetically regulated immune responses that promote lung injury. To study genetic mechanisms of immune-mediated coronavirus pathogenesis, we screened the Collaborative Cross (CC) panel for Mus musculus strains that are phenotyp...

Ellen L. Risemberg, S. Leist, A. Schäfer et al. · 0 citations
Open access Aug 2026

DetectGxT: detecting gene-by-treatment interactions on molecular count phenotypes accounting for allelic additivity

An R software package is developed that uses nonlinear regression to more accurately model the relationship between the genotype and the transformed molecular count phenotypes and suggests an advantage of nonlinear regression over linear regression in detecting G×T interactions on molecular phenotypes.

Yuriko Harigaya, Michael I. Love, W. Valdar · 0 citations

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