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Sep 2026

LPCAT3 is essential for leukemia progression and represents a therapeutic vulnerability in AML

RNA-seq following LPCAT3 loss showed that genes differentially expressed were significantly enriched in granulocyte chemotaxis–related pathways, suggesting a role of LPCAT3 in modulation of leukemic differentiation programs and microenvironmental interactions, established that LPCAT3 as a previously unrecognized mediat...

Mu-Tian Cao, L. Cong, Yi-Fei He et al. · 0 citations
Aug 2026

SETD5 regulates leukemic initiation and infiltration in T-cell acute lymphoblastic leukemia.

It is demonstrated that SETD5 contributes to T-ALL progression by regulating transcriptional programs that contribute to leukemic cell migration and infiltration, suggesting that SETD5-associated transcriptional programs warrant further investigation as potential vulnerabilities in T-ALL.

Ming-Yue Hao, Yu-Jie Bian, Mengke Li et al. · 0 citations

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