Cancer-associated fibroblast-derived POSTN as a metabolic “switch” shapes lipid-stressed macrophage polarization in gastric cancer
Background Cancer-associated fibroblasts (CAFs) foster an immunosuppressive tumor microenvironment (TME) and confer resistance to immune checkpoint blockade (ICB) in gastric cancer (GC). However, the mechanisms by which specific CAF subsets regulate metabolic crosstalk and immune evasion remain poorly defined. Methods...