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EBV-driven Gate–License–Amplify circuit in multiple sclerosis pathogenesis
Five recent publications establish a “ Gate – License – Amplify ” circuit that mechanistically links Epstein – Barr virus (EBV) infection and genetic risk (HLA-DR15) to the pathogenesis of multiple sclerosis (MS). 1 – 5 This new model reveals how EBV reprograms immuno-peptidomes to trigger CNS autoimmunity, providing a...