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Author

Wan-Tao Wu

2 papers indexed here

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Open access Aug 2026

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background: Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods: We integrated advanced biological network analyses with multimodal AI to identify CTSB as a k...

Hao Zhang, Nan Zhang, Xisong Liang et al. · 0 citations
Open access Jul 2026

Integrative single-cell and spatial transcriptomic analysis reveals a lactate-driven crosstalk between NFATc4⁺ tumor cells and SPP1⁺ macrophages in glioblastoma.

BACKGROUND Glioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options. Metabolic reprogramming, particularly lactate metabolism, plays a critical role in tumor progression and immune evasion. METHODS Here, we integrated single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and machine...

Ruoli Wang, Wan-Tao Wu, Xuan Wu et al. · 0 citations

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