Sep 2026
A Peptidoglycan-Mimetic Nanopore Receptor Resolves Glycopeptide Antibiotic Recognition and Resistance at the Single-Molecule Level.
Glycopeptide antibiotics (GPAs) are a critical class of last-resort therapeutics for treating severe infections caused by multidrug-resistant Gram-positive bacteria. However, their highly similar molecular structures and binding mechanisms make accurate discrimination and mechanistic analysis challenging. Here, we repo...
Zhuo-Qun Su, Liu-Xin Jiao, Jing-Xian Hou et al.
· ACS Sensors · 0 citations