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Review Oct 2026

Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation.

Mitochondria and their biomacromolecular complexes-such as the electron transport chain (ETC), mitochondrial permeability transition pore (mPTP), and protein quality control systems-play pivotal roles in aging and age-related diseases. This review integrates recent insights into how structural and functional disruption...

Xiao-Fang Zhang, Tao Tao, Wan-Yi Liu et al. · 0 citations
Open access Aug 2026

Prognostic and biological significance of MRPL13 in multiple myeloma: evidence from multi-cohort, single-cell analyses

Background Multiple myeloma (MM) is a clonal plasma cell malignancy with high heterogeneity and poor prognosis. Mitochondrial ribosomal protein L13 (MRPL13) has been linked to tumor progression, but its role in MM remains unclear. Methods We analyzed seven datasets comprising 3,117 patient samples from the Multiple Mye...

Wanyi Liu, Changjian Yan, Huiqiang Wu et al. · 0 citations

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