Orthoflaviviruses use diverse binding modes to engage LDLR family receptors
Cryo-electron microscopy structures of yellow fever virus (YFV) E bound to low-density lipoprotein receptor-related protein 4 (LRP4) and LRP8, and of tick-borne encephalitis virus (TBEV) E bound to LRP8 are determined, identifying key determinants of receptor specificity for these two orthoflaviviruses.