Wan-Zhuo Chen

Cartilage-targeting engineered probiotic bacterial extracellular vesicles treat osteoarthritis through modulation of matrix homeostasis

Reversing extracellular matrix (ECM) metabolic dysregulation to facilitate cartilage repair represents a key therapeutic strategy for osteoarthritis (OA) treatment. Owing to the avascular nature of joint structures, intra-articular injection is a commonly used clinical administration route. However, the current drug re...