Wang-Wei Ao

Discovery of novel imidazopyrazine derivative as a KIF18A inhibitor.

KIF18A, a plus-end mitotic kinesin critical for spindle integrity in chromosomally unstable (CIN) tumors, represents a synthetic-lethal target for anti-mitotic therapy. Herein we report the discovery of compound 19d, a novel imidazopyrazine featuring a spiro-bridged amine that potently inhibits KIF18A (IC50 = 52 nM) an...