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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Wang-Wei Zhang

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Open access Sep 2026

Saikosaponin A Induces Apoptosis in HCT116 Colorectal Cancer Cells via ROS-Mediated ER Stress and p38/JNK MAPK Pathway Activation: in Vitro and in Vivo Evidence

Colorectal cancer (CRC) is the third most prevalent cancer globally, with limited effective treatment options and significant chemotherapy resistance. Saikosaponin A (SSA), a triterpenoid saponin from Radix Bupleuri, exhibits anti-inflammatory and antitumor properties, but its mechanism of action in CRC remains und...

Xiu-Xiu Zhang, Jing-Ling Yang, Wang-Wei Zhang et al. · 0 citations

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