Programmed cell death (PCD) is a major regulatory mechanism that maintains tissue homeostasis and immune balance and strongly influences the initiation, progression and resolution of inflammation. Although apoptosis, pyroptosis, necroptosis and ferroptosis are individual PCD modes that are regulated by different molecu...
Wangzheqi Zhang, Cheng-Long Zhu, Chun-Zhen Li et al.· Cellular & Molecular Immunol...· 0 citations
Sepsis is a life-threatening syndrome defined by infection-triggered dysregulation of the host response, and its persistently high mortality and marked clinical heterogeneity remain major barriers to early risk stratification and individualized management. While the gut is increasingly recognized as a key modulator of...
Shi-Yang Zhang, Li-Zhou Song, Yan Liao et al.· Ageing Research Reviews· 0 citations
Sepsis often leads to severe liver damage, and currently few effective therapies are available for it. Nicotinamide mononucleotide (NMN), a well-known anti-aging agent, exerts organ-protective effects, yet its detailed mechanisms against acute liver injury remain poorly understood. Here, we established LPS-induced live...
Yan Liao, Cheng-Long Zhu, Wangzheqi Zhang et al.· Pharmacological Research· 0 citations
Heart failure (HF) is a significant global health issue, and its complicated pathogenesis needs to be further clarified. In recent years, non-coding RNAs (ncRNAs) have emerged as key players in the development and pathogenesis of HF; nonetheless, their systemic regulatory networks and clinical translational capacity ne...
Yu-Jie Wang, Xuan Yin, Hao-Ling Zhang et al.· Translational Research: The...· 0 citations
Ischemia-reperfusion injury (IRI) contributes to the pathogenesis of major diseases, including acute kidney injury, stroke, and myocardial infarction. Multiple forms of cell death, including apoptosis, necroptosis, pyroptosis, autophagy, and ferroptosis, are key contributors to IRI. The interplay among these cell-death...
Chuan-Gang Yao, Qi Wu, Zhi Wang et al.· Biomarker Research· 0 citations
This review summarizes recent advances in microglial biology across acute brain injury, neurodegenerative and demyelinating disorders, central nervous system infections, and psychiatric and neurodevelopmental diseases and provides new opportunities for precision therapy.
Jie Chen, Wangzheqi Zhang, Li-Zhou Song et al.· Clinical and Translational M...· 0 citations
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